April 16, 2024
Prascend for horses

Prascend for horses || Administering Prascend

Introduction About the Prascend for horses

Prascend for horses, also known as Pituitary Pars Intermedia Dysfunction (PPID), is a common condition affecting older horses and ponies. It is caused by a benign tumor in the pituitary gland, leading to an overproduction of certain hormones, including cortisol. This hormonal imbalance results in a range of symptoms that can significantly affect a horse’s quality of life. It includes excessive thirst and urination, a long, curly coat that fails to shed. It increased susceptibility to infections, and laminitis—a painful inflammation of the hoof. Given these severe implications, understanding and managing Equine Cushing’s Disease is crucial for horse owners and veterinarians alike.

The Importance of Managing Equine Cushing’s Disease

Managing Equine Cushing’s Disease is paramount for several reasons. Firstly, it helps improve the quality of life for affected horses, allowing them to live more comfortably despite their condition. Proper management can also extend a horse’s lifespan by mitigating the risk of complications associated with the disease, such as laminitis, which can be life-threatening. Furthermore, effective management includes monitoring for and treating concurrent conditions that horses with PPID are more susceptible to, such as infections and dental disease. As such, understanding treatment options like Prascend becomes essential in the holistic care of horses with this condition.

What is Prascend?

Prascend is the trade name for pergolide mesylate, a medication that has been specifically designed to treat Equine Cushing’s Disease. Pergolide, the active ingredient, is a dopamine agonist that works by mimicking the action of dopamine, a neurotransmitter that is deficient in horses with PPID. This deficiency leads to the excessive production of pituitary hormones. By supplementing the horse’s system with pergolide, Prascend helps normalize the hormone production of the pituitary gland, thus controlling the symptoms of Cushing’s Disease.

The Science Behind Prascend

The science behind Prascend is grounded in its action on the pituitary gland. In horses with PPID, the pituitary gland enlarges and produces hormones in excess due to a reduction in the regulatory influence of dopamine. Pergolide mesylate, by acting as a synthetic form of dopamine, restores the missing inhibitory effect, thereby normalizing the secretion of hormones. This mechanism of action is crucial in the management of PPID, as it addresses the hormonal imbalance at its source.

How Prascend Works in Horses

Once administered, Prascend begins to exert its effects by binding to dopamine receptors in the pituitary gland. This binding reduces the overproduction of adrenal hormones, such as cortisol, which are responsible for the symptoms of Cushing’s Disease. By doing so, it alleviates the clinical signs associated with the disease, such as muscle wastage, abnormal fat distribution, and insulin resistance. Horses on Prascend often show a noticeable improvement in their condition, including a more normal shedding pattern, reduced thirst and urination, and a decrease in the risk of laminitis.

Benefits of Prascend for Horses

Improved Quality of Life

One of the most significant benefits of Prascend is the improvement in the quality of life it offers horses with PPID. By controlling the symptoms of Cushing’s Disease, horses can enjoy a more normal existence, engaging in regular activities and interactions without the burden of excessive physical discomfort. Owners often report their horses have more energy and show an interest in their surroundings, indicative of better overall well-being.

Management of Clinical Signs

Prascend plays a critical role in managing the clinical signs of Equine Cushing’s Disease. Regular administration of this medication can lead to a reduction in the coat abnormalities that are characteristic of PPID, helping horses to shed their coats more effectively. It also mitigates the risks associated with the excessive production of cortisol, such as laminitis and susceptibility to infections, thereby protecting the horse from potentially life-threatening conditions. Additionally, by managing the clinical signs of PPID, Prascend helps stabilize the horse’s metabolic state, reducing the likelihood of insulin resistance and diabetes.

Administering Prascend

Dosage and Administration Guidelines

Prascend, containing the active ingredient pergolide mesylate, is the only FDA-approved. The medication for the control of clinical signs associated with PPID in horses. The starting dose typically recommended is 2 micrograms of pergolide per kilogram of body weight, administered once daily orally. The tablet can be given by placing it directly on the horse’s. The tongue or mixed with a small amount of feed to ensure consumption. Consistency in the time of day the medication is given can also help in maintaining stable drug levels in the horse’s system. Given the variance in how individual horses may respond to treatment, it’s essential to follow a vet’s specific recommendations for your horse.

Monitoring and Adjustments

Regular monitoring, through clinical assessments and laboratory tests, is key to determining the effectiveness of Prascend and whether any dosage adjustments are necessary. Periodic reevaluation of ACTH levels, typically every 6 to 12 months, can guide these adjustments. Signs of improvement in clinical symptoms, such as reduction in excessive hair growth. It increased energy levels. The normalization of drinking and urination habits indicates effective management of PPID. If a horse does not show expected improvement, the veterinarian may suggest increasing the dosage incrementally, closely monitoring for any side effects. It’s critical to never adjust the dosage without veterinary guidance.

Also, visit my other post. Equine Influenza Transmission

Potential Side Effects and Considerations

While Prascend is effective in managing PPID in horses, as with any medication, there are potential side effects. Awareness of these and knowing when to seek veterinary advice are crucial aspects of care.

Common Side Effects

Some horses may experience side effects, which are generally mild and diminish with time. These can include:

  • Decreased appetite
  • Behavioral changes, such as lethargy or depression
  • Diarrhea
  • Colic signs

In most cases, these side effects are temporary, resolving as the horse’s system adjusts to the medication. Sometimes, a temporary reduction in dosage, followed by a gradual increase, can help mitigate these effects.

When to Consult a Veterinarian

Immediate veterinary consultation is recommended if any of the following occur:

  • Severe or persistent side effects
  • Signs of colic or significant changes in bowel movements
  • Any new or worsening health concerns

Moreover, regular check-ins with your vet are essential to assess the ongoing effectiveness of the treatment and to make any necessary adjustments. Keeping an open line of communication ensures the health and well-being of horses undergoing treatment for PPID with Prascend.

FAQs to the Prascend

How quickly can improvements be seen after starting Prascend?
Improvements in symptoms of Equine Cushing’s Disease can be observed as early as 3 to 4 weeks after starting Prascend. However, it can take several months for the full benefits to become apparent, as the medication works to gradually normalize hormone levels.

Can Prascend be used in conjunction with other medications?
Yes, Prascend can be used alongside other medications, but it’s essential to consult with a veterinarian. They will consider potential interactions and adjust treatments to ensure the safest and most effective care plan for the horse, especially when managing multiple conditions.

How long does a horse need to be on Prascend?
Prascend is typically a lifelong therapy for horses diagnosed with Equine Cushing’s Disease. Since the disease is chronic and progressive, ongoing treatment with Prascend helps manage the symptoms and improve quality of life, but it does not cure the condition.

Are there any dietary considerations while a horse is on Prascend?
Dietary management is crucial for horses on Prascend, particularly focusing on low-sugar and starch diets to support overall health and mitigate any risk of laminitis. A balanced diet, often with increased fiber, and adjusted calorie intake based on the horse’s condition and weight, is recommended. Always consult a veterinarian for a tailored feeding plan.


Managing Equine Cushing’s Disease (PPID) requires a comprehensive approach. Prascend plays a pivotal role in mitigating the symptoms and improving the quality of life for affected horses. The journey through understanding Equine Cushing’s Disease, the benefits, and the administration of Prascend, along with navigating potential side effects, underscores the necessity of close veterinary supervision and care. It’s clear that Prascend. When they are used responsibly under veterinary guidance, offers a beacon of hope for horses suffering from this condition. However, it’s also evident that treatment with Prascend is not a one-size-fits-all solution. Each horse’s needs must be assessed individually, considering potential interactions with other medications and the importance of dietary management.

Leave a Reply

Your email address will not be published. Required fields are marked *

We use cookies to personalise content and ads, to provide social media features and to analyse our traffic. We also share information about your use of our site with our social media, advertising and analytics partners. View more
Cookies settings
Privacy & Cookie policy
Privacy & Cookies policy
Cookie name Active
Save settings
Cookies settings